Furthermore, Corrado and colleagues showed that CML-derived small EVs are enriched in amphiregulin (AREG), which cause aberrant activation of EGFR in MSCs, ultimately leading to increased expression of SNAIL and its targets, such as MMP9 and IL8 [192]. This evidence concerns the gene CXCL8 and chronic myelogenous leukemia, BCR-ABL1 positive.