AKT1 and B-cell chronic lymphocytic leukemia: In order to maintain a favorable microenvironment, CLL cells were demonstrated to release small EVs which has the potential to sustained the activation of the AKT, mTOR, p70S6K and HIF-1α pathways, furthermore they modulate the AKT-GSK3β or AKT-β-catenin signaling pathways [189].