IL23R and colitis: As we intended to use the generated REX-secreting L. lactis recombinant strains for in vivo testing, as antagonists of the IL-23R in the mouse model of experimentally induced colitis, we generated a homology model of the murine IL-23R, based on the crystal structure of the human IL-23/IL-23R complex available in the PDB database, and tested the binding ability of particular REX variants by docking.