ITSN1 and Iron deficiency anemia: Iron deficiency altered methylation at the genes regulating ephrin B signaling/ephrin receptor signaling (data not shown), including increased methylation at Ephb1, Itsn1, Prkar1b, and Srgap2, and decreased methylation at Arhgef15, Mknk1, and Slit3 loci (Table 1).