Most of these TRIMs, like TRIM11 [70,71,72,73,74], TRIM23 [75], TRIM24 [76], TRIM25 [77,78,79], TRIM31 [80], TRIM37 [81], TRIM47 [82,83], TRIM65 [84], and TRIM71 [85] are up-regulated in cancer cells and tissues, playing an oncogenic role in different types of cancer. The gene discussed is TRIM31; the disease is cancer.