To gain insight into the molecular basis of the anti-obesity effect of AM-Ex, we examined the expression levels of adipogenic transcription factors, including CCAAT/enhancer binding protein α (C/EBPα), peroxisome proliferator-activated receptor γ (PPARγ), and sterol regulatory element-binding protein-1c (SREBP-1c) and their target genes, in epididymal adipose tissue. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.