Interestingly, in mouse models known to develop SqD or high-grade disease including BBN treated mice (Figure 6e–h), UpkII-SV40T (Figure 6m–p), UpkII-SV40T/HRAS*/WT (Figure 6q–t), and UBC-Cre/ERT2/Foxa1loxp/loxp (Figure 6u–x) we observed overexpression of Hdac4 and/or Hdac9 as well altered cellular localization suggesting in these models Hdac4 and -9 are important in the development of hyperplasia and/or CIS in vivo. Here, HRAS is linked to in situ carcinoma.