Increasing evidence suggests that YAP1 has diverse roles in tumorigenesis and drug resistance [20], and it has been reported to promote malignant features (e.g., cell proliferation, invasion, migration, and anti-apoptosis) [20,128,129,130,131,132] and drug resistance in various cancers, including breast, bladder and lung cancer (Figure 2) [51,52,133]. The gene discussed is YAP1; the disease is cancer.