NFKB1 and liver disorder: Likewise, it has been reported that the PPARa factor, which is stimulated by the polyphenols present in S. edule, interferes with the signaling of pro-inflammatory transcription factors, including the signal transducer and activator of transcription (Stat), the activator protein-1 (AP-1) and NF-κB, from which derives the proposal to investigate agonist molecules of this receptor in order to find substances with therapeutic potential to treat inflammatory liver diseases.