Gain-of-function ABCC8 and KCNJ11 gene mutations have been reported to cause rare forms of MODY (ABCC8-MODY 12 and KCNJ11-MODY13) with variable clinical presentation, ranging from asymptomatic glucose intolerance to overt diabetes, with age [77]. This evidence concerns the gene KCNJ11 and Glucose intolerance.