EGFR and ERBB2 activation in LNCaP cells under the influence of osteoblast-derived sarcoma cells (OHS) has been reported to activate EGFR/ERBB2 signaling pathways in LNCaP cells co-cultured with osteoblastic cells that had been differentiated from human mesenchymal stem cells or OHS cells. The gene discussed is ERBB2; the disease is sarcoma.