The study with the use of genome-wide DNA methylation quantitative trait locus (mQTL) analysis identified several hundred cytosine-phosphate-guanine (CpG) sites, including known diabetes loci, e.g., ADCY5, KCNJ11, HLA-DQA1, INS, PDX1, GRB10, showing significant association with the insulin secretion and diabetes risk [17]. This evidence concerns the gene INS and diabetes mellitus.