POLE and cancer: Thus, like inactivation of mismatch repair genes (MLH1 and MSH2), BRCA genes (BRCA1 and BRCA2), and DNA polymerase genes (POLE), overexpression of APOBEC3B, and reduced expression of DNA glycosylase genes (NEIL1, NEIL2, and MUTYH) [31,32,33,34,35], POLQ overexpression is likely to be another cancer-related gene abnormality associated with mutagenesis of the entire coding genome.