In a similar mouse model, using human proteoglycan aggrecan to induce arthritis it was described that in the T cells of immunized BALB/c mice reduced activation induced cell death was observable after in vitro anti-CD3 stimulation, as an altered expression of FLIP inhibited the relocation of Caspase-8 to the DISC [66]. This evidence concerns the gene CASP8 and arthritic joint disease.