The data showed that the hub gene expression of RPL36A, AP1S1, MRPL35, AKAP12, SHC1, ERBB2, PDLIM7, PCSK5, and MUC1 were increased (Figure 17), while that of expression of ALPL was reduced (Figure 18) in GBM compared with those in the normal patients. The gene discussed is SHC1; the disease is glioblastoma.