Meanwhile, for GO enrichment analysis for down regulated genes, genes such as GSN [151], FSCN1 [152], and PHLDB2 [153] were important for the invasion of many cancer types such as pancreatic cancer, bladder cancer, and colon cancer cells, but these genes may be involved in the invasion of GBM. The gene discussed is PHLDB2; the disease is malignant colon neoplasm.