ACTN1, COL4A5, COL6A2, LAMB2, P3H1, COL15A1, COL16A1, PCOLCE2, PCOLCE, PCSK5, IK3IP1, MFAP4, FAM20C, C1QTNF1, PLXNA3, and NTNG1 were identified as novel biomarkers for the pathogenesis of GBM. The gene discussed is COL4A5; the disease is glioblastoma.