Genes such as ERBB2 [121], PDGFRA [122], PDGFRB [123], ITGA5 [124], AKT1 [125], COL1A1 [126], COL6A1 [127], THBS2 [128], PLOD2 [129], P4HA1 [130], IL10 [131], SPARC [132], IL18 [133], SRPX2 [134], CCL2 [135], PLAT [136], PLAU [137], CXCL12 [138], SFRP2 [139], ANGPT1 [140], CXCL14 [141], TGM2 [142], FSTL1 [143], IGFBP5 [144], IGFBP7 [145], LOX [146], and LOXL1 [147] were diagnosed with the development of GBM. The gene discussed is PLAU; the disease is glioblastoma.