CTSO and lung cancer: Meanwhile, pathway enrichment analysis for down regulated genes, genes such as MYL5 [93], CAV2 [94], BMP1 [95], COL5A1 [96], SERPINH1 [97], COL7A1 [98], COL8A1 [99], COL13A1 [100], BGN [101], SEMA4B [102], ECM1 [103], TGFB3 [104], ANGPTL2 [105], MUC1 [106], and CTSO [107] were responsible for the invasion of many cancer cells such as cervical cancer, triple-negative breast cancer, lung cancer, esophageal squamous cell carcinoma, urothelial carcinoma, gastric cancer and breast cancer, but these genes may be liable for the invasion of GBM cells.