In human cells, transcript levels of the BAF–SWI/SNF subunit Brahma-associated factor 53a (BAF53A) has been found to be amplified in head and neck squamous cell carcinoma (HNSCC) along with p63. BAF53A and p63, a DNA-binding transcription factor, form a complex to activate the expression of target genes that promote proliferation and prevent differentiation in HSNCC [31]. This evidence concerns the gene ACTL6A and head and neck squamous cell carcinoma.