The simultaneous expression of PD-1 and CTLA-4 is associated with a higher tumor stage (p ≥ T3, p = 0.037, not significant with Bonferroni correction, correlation coefficient 0.119) and a high grade tumor (G3, p = 0.005, not significant with Bonferroni correction, correlation coefficient 0.159), as well as with primary metastatic diseases (p < 0.001, correlation coefficient 0.200). This evidence concerns the gene CTLA4 and metastatic neoplasm.