CTLA4 and neoplasm: In primary non metastatic patients, only a high tumor grade (G3, HR = 4.4, p = 0.001), CTLA-4 expression (HR = 2.5, p = 0.005), and the combination of PD-1 and CTLA-4 expression (HR = 16.3, p < 0.001) are significantly associated with a worse CSS (Table S2).