CAFs become activated by several tumor-derived growth factors, such as transforming growth factor-β (TGFβ), fibroblast growth factor (FGF), platelet-derived growth factors (PDGFs), epidermal growth factors (EGFs), bone morphogenic proteins (BMP) and sonic hedgehog (SHH) as well as cytokines that are present in the surrounding milieu [2,18]. This evidence concerns the gene TGFB1 and neoplasm.