In this study, we demonstrated an in vitro tumor environment-based paracrine regulation in which MSC-derived exosomal miR-155 suppressed SMARCA4 expression through enhancing tumor initiation, and simultaneously miR-155 direct targeting brahma-related gene-1 (BRG-1) 3’UTR and secretion leading to the promotion of tumorigenicity. Here, SMARCA4 is linked to neoplasm.