In adipose tissue, DNL declined according to the degree of obesity and insulin resistance status from C57Bl6 (1.21 ± 0.18) to alb-SREBP-1c (0.93 ± 0.07) and obob mice (0.83 ± 0.07) (Figure 2A). The gene discussed is SREBF1; the disease is obesity due to melanocortin 4 receptor deficiency.