In the present study, we compare the adipokinomes of mice with increased hepatic DNL by the genetic overexpression of the N-terminal domain of SREBP-1c [7], as a model for “healthy” obesity, with hyperphagia-induced morbid obese mice (obob), as model for “sick” adipose tissue or lean mice (C57Bl6) by label-free proteomics. Here, SREBF1 is linked to obesity due to melanocortin 4 receptor deficiency.