In addition, the number and significance of the proteins related to steatosis processes gradually increased with the severity of obesity in the comparisons of C57Bl6 vs. alb-SREBP-1c (n = 20, p-value 3.35 × 10−7), C57Bl6 vs. obob (n = 28, p-value 8.9 × 10−9), and obob vs. alb-SREBP-1c (n = 39, p-value 9.5 × 10−17) (Figure 5). This evidence concerns the gene SREBF1 and obesity due to melanocortin 4 receptor deficiency.