RHO and carcinoma: For example, α3β1 (an LN receptor) and α5β1 (an FN receptor) were each found to be required on CAFs for protease- and force-mediated ECM remodeling to generate matrix tracks that guide collective invasion of adjacent carcinoma cells, with indications that these two integrins work through distinct signaling pathways (Rho-dependent in CAFs; Cdc42-dependent in carcinoma cells) [87].