In particular, overexpression of the four main intracellular players of the alternative pathway (NF-κB2, RelB (transcription factor RelB), NIK (Mitogen-activated protein kinase kinase kinase 14) and Bcl3 (B-cell lymphoma 3 protein) has been identified in primary NSCLC compared to normal tissues and association of their expression with lymph node infiltration and overall survival (OS) has been revealed [6,7,8]. The gene discussed is RELB; the disease is non-small cell lung carcinoma.