Notably, unlike single agent checkpoint inhibitor trials, benefit was only seen in the group of tumors that expressed PD-L1 within the immune infiltrate and, as such, the combinatorial strategy has been recently FDA approved for unresectable locally advanced or metastatic TNBC patients who have PD-L1 stained tumor-infiltrating immune cells covering at least ≥1% of the tumor area (https://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm633065.htm). The gene discussed is CD274; the disease is neoplasm.