CD274 and neoplasm: Specifically, patients with metastatic NSCLC and PDL1 tumor proportion score of at least 50% can be treated with front-line single agent pembrolizumab, while patients with PDL1 levels below 50% can receive immunotherapy in combination with chemotherapy (i.e., carboplatin-pemetrexed-pembrolizumab, carboplatin-taxane-pembrlizumab combinations) in the frontline setting or one of three single-agent immunotherapy agents (pembrolizumab, nivolumab, or atezolizumab) in the second-line setting for relapsed disease [27,28,29].