Another study on hypoxic tumor cells showed that hypoxic glioblastoma cells secrete exosomes that were enriched in hypoxia-regulated proteins, such as matrix metalloproteinases (MMPs), platelet-derived growth factors (PDGFs), Interleukin-8 (IL-8), caveolin 1 and lysyl oxidase, and mRNAs, and were able to induce angiogenesis [55]. This evidence concerns the gene CXCL8 and neoplasm.