IL6 and neoplasm: Studies describing this cell non-autonomous pro-tumorigenic function include epithelial-mesenchymal transition and invasion, tumor vascularization, immune surveillance, and abnormal tissue morphology, mediated by proinflammatory cytokines IL-6 and IL-8, metalloprotease MMP3 and VEGF among others [87,89,91,92,93,94,95].