CD8A and head and neck cancer: Similar data has been reported impacting HPV-driven head and neck cancers in a preliminary report [27], where a similar genetically-adjuvanted HPV DNA vaccine has been shown to drive an increase in intratumoral T cell infiltration by CD8 cells, as well as result in complete clinical regression in metastatic head and neck cancer when the vaccine was followed by PD-1 immunotherapy (this outcome was observed in 2/4 patients).