Although triggering TLR3 signaling induces the activation of multiple proinflammatory pathways (as NFκB and IRF3 signals) [38], it is likely that in our system the baculovirus component in combination with Poly (I:C) strongly drove the innate response toward a favorable recognition of viral components rather than toward the tumor antigen, due to the synergetic effect of the activation of TLR9 and TLR3. This evidence concerns the gene NFKB1 and neoplasm.