NECTIN4 and neoplasm: As there was no information available from literature concerning Nectin 4 impact on overall survival (OS) in HGSOC, we exploratively assessed the optimal cutoff by non-linear modeling of the Nectin 4 impact on OS by fractional polynomials Cox regression estimation [26] correcting for the known clinicopathologic factors age, FIGO stage, grade, and residual tumor mass after debulking surgery.