While it is notable that HCP5 is often in LD with the HLA class I genes and that their expression is often coordinated in response to various stimulators or suppressors, functional interactions between the products of these genes suggest that HCP5 has an associated role in antigen processing and presentation, the proteasome, graft versus host disease, allograft rejection, autoimmune disease, response to type 1 interferon or interferon gamma, and in the regulation of viral reproduction, especially in HIV restriction [6,14,24,50,52,107]. This evidence concerns the gene IFNG and autoimmune disease.