Luciferase reporter gene assay also showed that miRNA-15a bound directly to either HCP5 or MACC1. Because HPV16 and HPV18 are associated strongly with cervical cancer progression, the question arises whether the PMSP gene [38] of HCP5 is also expressed and what role it might have with the increased proliferation of cervical cancer cells. This evidence concerns the gene MACC1 and cervical cancer.