Previously, Orvis et al. [135] showed that inactivation of the BRG1 gene, also known as SMARCA4, which encodes the ATPase subunits of the SW1/SNF chromatin remodeling complex, contributed to non-small cell lung cancer aggressiveness by altering nucleosome positioning in a wide range of genes as well as by downregulating the expression of HCP5 and all of the classical and nonclassical HLA class I genes. The gene discussed is SMARCA4; the disease is non-small cell lung carcinoma.