In some cancers, TGFbeta might induce HCP5 transcription via the activity of SMAD3 [56], and increased levels of HCP5 RNA might either directly or indirectly affect GSR, ASCL1, MET, GRM8, DACHI [152], ETN3A1, ETN3A3, CCDC50, HERC6, TAP1, and PSMB9 [164] as well as many other genes (Table 6). This evidence concerns the gene HCP5 and cancer.