HCP5 and obesity due to melanocortin 4 receptor deficiency: In an epigenome-wide association study using whole blood measures of adiposity in 547 Ghanaian African migrants, Meeks et al. [64] found that obesity and body mass index (BMI) were related to HCP5 hypermethylation and 18 differentially methylated positions (DMPs) for BMI, 23 for waist circumference, and three for obesity.