In a system-wide association study between DNA methylation, gene expression, and humoral immune response to influenza [124], a cohort of 158 individuals who were 50 to 70 years old showed that HCP5 along with HLA-B and HLA-DQB2 had an important role in methylation expression, particularly when the humoral immune response to influenza was measured by a hemagglutination inhibition assay (HAI). This evidence concerns the gene HLA-DQB2 and influenza.