In fact, a high percentage of CKD patients are treated with diuretics to reduce edema, anti-hypertensive drugs, ACE-inhibitors to treat proteinuria, phosphate binders to prevent secondary hyperparathyroidism and vascular calcification, sodium bicarbonate to correct metabolic acidosis, and erythropoietin to treat anemia [5]. This evidence concerns the gene EPO and secondary hyperparathyroidism.