The antitumour activity of the glycosyl modified BISAs derivatives that may bind well to c-Met have been studied and is shown to target multiple kinases capable of inhibiting cancer progression to metastases [15,16], therefore, we selected several new BISAs compounds containing isothiourea, tetramethylthiourea and heterocyclic groups for chemical synthesis and evaluated their biological activities. This evidence concerns the gene MET and cancer.