The CSPG4 antigen (chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan, MCSP, or high molecular weight melanoma-associated antigen, HMW-MAA) is expressed in 90% of melanoma lesions [25] and other malignancies, e.g., gliomas and sarcomas [26,27]. This evidence concerns the gene CSPG4 and melanoma.