In this context the “safer” receptor, which is lentivirally transduced into the T cells using receptor-encoding DNA (e.g., the CD19 CAR or the gp100 TCR) should have a strong and permanent anti-tumor effect, whereas the “more dangerous” receptor, that is transfected into the same T cell using receptor-encoding RNA (e.g., the CD123 CAR or Her2/ERBB2 CAR), should have an additional “boost” effect at the beginning of the therapy. Here, CD19 is linked to neoplasm.