HLA-C and neoplasm: This could be circumvented by, e.g., co-transfection of the T cells with a CAR and a TCR: While TCRs recognize intracellular tumor antigens that are presented on the cell surface by major histocompatibility complex (MHC) molecules [17], CARs bind to unprocessed tumor surface antigens independent of MHC restriction and antigen processing [18,19].