The expression of MT1-MMP has been associated with poor prognosis in patients with melanoma, pancreatic cancer, advanced neuroblastoma, small cell and non-small cell lung cancer, mesothelioma, tongue squamous cell carcinoma, head and neck carcinoma, bladder cancer, breast cancer, colorectal cancer, and ovarian cancer [2,3,4,5]. Here, MMP14 is linked to breast cancer.