NFE2L2 and colitis: In fact, a recent study by Singh et al. [53] showed that urolithin A and its potent synthetic analogue protected from 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced or DSS-induced colitis through enhancement of gut barrier function by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.