Recently, the JUPITER study confirmed that HDL particle number was the only predictor of incident CV disease (41), and the China Kadoorie Biobank prospective study established that a 1-SD increase in very large, large, and medium HDL cholesterol particles significantly reduced myocardial infarction risk (13% and 20% reduction in risk), and a 1-SD increase in apoA-I reduced myocardial infarction risk by 11% (42). Here, APOA1 is linked to myocardial infarction.