Interestingly, in patients with high Cripto-1 expression, the results showed that without received TACE (P = 0.019), larger tumor size (P = 0.01), multiple tumor (P = 0.001), satellite nodule (P = 0.025) and vascular invasion (P = 0.005) were unfavourable factors for TTR in HCC patients. This evidence concerns the gene TTR and hepatocellular carcinoma.