To assess whether this initiator activity is a general characteristic of exosomes from all cell types or a trait unique to exosomes derived from KRAS mutated pancreatic cancer cell lines, we repeated experiments with exosomes from three additional cell types: BxPC-3 cells, a pancreatic cancer cell line with WT KRAS, HPDE cells, a normal human cell line, and primary dermal fibroblasts. This evidence concerns the gene KRAS and pancreatic neoplasm.