In the allele model, we discovered that rs791588 (IL2RA) and rs2281089 (IL2RB) significantly decreased the risk of RA in females (rs791588: OR = 0.49, 95% CI = 0.30–0.82, p = 0.006) and people aged under 54 (rs2281089: OR = 0.37, 95% CI = 0.21–0.68, p = 0.001 and OR = 0.72, 95% CI = 0.56–0.93, p = 0.011). Here, IL2RB is linked to rheumatoid arthritis.