Its upregulation in β‐thalassemia may be indicative of myelofibrosis, or an inflammation and scarring of the bone marrow, seen also in Philadelphia‐negative chronic myeloproliferative neoplasms where there is an exceedingly high level of expression of IFI27 in whole blood (Gorden et al., 2013). Here, IFI27 is linked to myelofibrosis.