A more recent study of iPSCs derived from SZ patients carrying a four base-pair deletion in Disrupted-in-schizophrenia 1 (DISC1), a gene that co-segregates with major psychiatric disorders, has reported aberrant synaptic formation and synaptic vesicle release deficits in patient-derived neurons (Wen et al., 2014). Here, DISC1 is linked to psychiatric disorder.