RELN and epilepsy: Indeed, Reelin signaling dysfunction has been documented in several neurodevelopmental and neurodegenerative disorders including AD, PD, HD, and epilepsy (Haas et al., 2002; McCullough et al., 2012; Bodea et al., 2014; Baek et al., 2015; Cuchillo-Ibanez et al., 2016).