More interestingly, expression of PD-associated VPS35 D620N mutant elevates phosphorylation of Rab GTPases (Namely Rab8A, Rab10, and Rab12) and increases overall kinase activity of LRRK2 to a greater degree than PD pathogenic mutations (Mir et al., 2018). This evidence concerns the gene RAB10 and Parkinson disease.