The mammalian target of rapamycin (mTOR)-related signaling pathway has acquired increasing importance in seizure disorders, as somatic mutations of upstream and downstream signaling components, underlie cortical lamination deficits and the onset of focal cortical dysplasia and hemimegalencephaly, both neurodevelopmental disorders associated with seizures (Poduri et al., 2013). This evidence concerns the gene MTOR and epilepsy.