RELN and epilepsy: An exciting and recently described Reelin signaling modulator is the multi-scaffold protein Intersectin (ITSN), which acts as a guanine nucleotide exchange factor for Cdc42 and also functions as an essential scaffold for endocytic and exocytic processes at the pre-synapse, making it an interesting protein to study in pathological conditions associated with neurotransmitter release such as epilepsies (Gerth et al., 2017).