Tau protein hyperphosphorylation is a hallmark trait of AD (Pascoal et al., 2016), and studies combining microfluidics and co-cultures demonstrated that different tau phosphorylation states could be modeled within interconnected microfluidic neuronal cell compartments (Kunze et al., 2011b; Cho et al., 2013). The gene discussed is MAPT; the disease is Alzheimer disease.