It is plausible, in fact, that the administration of propranolol, a molecule able to reduce the production of VEGF, may be effective during the proliferative phase of ROP, when VEGF is dramatically increased and a reduction of VEGF is required, but detrimental if administered during the ischemic phase, when levels of VEGF are too low to permit a normal vascularization of the retina and an increase of VEGF is suitable. Here, VEGFA is linked to retinopathy of prematurity.