Furthermore, the inflammasome -derived IL-1β production was important to develop an efficient immune response against L. braziliensis, L. amazonensis, and L. chagasi infection (Lima-Junior et al., 2013) but it failed to induce resistance against the infection of the resistant C57BL/6 mice by L. major Seidman strain (LmSd) (Charmoy et al., 2016) or the hamster infection by L. donovani (Dey et al., 2018). This evidence concerns the gene IL1B and infection.