RAC1 and infection: Engagement of membrane prohibitin with Vi significantly inhibited activation of Cdc42 as well as Rac-1 during infection with Salmonella. These two GTPases are known to perform different functions during infection with this pathogen with Cdc42 contributing to inflammation and Rac-1 regulating pathogen invasion (Patel and Galán, 2006; Sun et al., 2018).