Since ELMO3 and ELMO1 have similar structures, including the ELMO domain, ras GTPase-binding domain (RBD), ELMO Inhibitor domain (EID), ELMO autoregulatory domain (EAD), the extreme C-terminal proline-rich motifs and PH domain (4, 15, 21), then ELMO3 may regulate NSCLC through similar mechanisms. This evidence concerns the gene ELMO1 and non-small cell lung carcinoma.