The prognostic signature observed in our study was linked to hypermethylation of ZNF671. Our findings reveal that ZNF671 is hypermethylated in BRCA, CESC, HNSC, KIRP, LUAD, PAAD, SARC, and UCEC, and functional assays established that ZNF671 inhibits tumor cell proliferation, migration, and invasion. This evidence concerns the gene ZNF671 and neoplasm.