Variants within ARHGAP22 have been associated with diabetic retinopathy, conduct disorder, daytime sleep, and self-employment (Dick et al., 2011; Huang et al., 2011; Van Der Loos et al., 2013; Spada et al., 2016), but these associations have not been replicated. This evidence concerns the gene ARHGAP22 and diabetic retinopathy.