Moreover, by exploring long-read RNA sequencing in the characterization of premature termination codons in ABCA7 in late-onset Alzheimer’s disease, De Roeck et al. (2017) observed various degrees of nonsense-mediated decay (NMD) and transcript modification that potentially influence ABCA7 dosage and disease severity. Here, ABCA7 is linked to early-onset autosomal dominant Alzheimer disease.