In addition, mRNA expression levels were all significantly higher in tumor tissues compared with those in normal tissues (BUB1B: t = -8.109, P < 0.001; CCNB1: t = -9.942, P < 0.001; CDK1: t = -9.784, P < 0.001; ISG15: t = -4.008, P < 0.001; KIF15: t = -3.781, P < 0.001; and RAD54L: t = -2.944,P = 0.005; Supplementary Figure S5C), which was suggested by the Oncomine database. This evidence concerns the gene ISG15 and neoplasm.