IL2RG and graft versus host disease: From the point of view of humanized mice construction, prkdc mutation was more suitable than Rag2, and (3) except for T-cells, B-cells, NK cells, neutrophils, macrophages, and cytokines could also cause a reaction of graft-versus-host disease, though the Rag2/IL2rg mutation reduced the number of neutrophils, lymphocytes in this study, residual granulocytes, macrophages, and cytokines might make it difficult for grafts to survive in mice.