KMT2A and acute myeloid leukemia: The same group further demonstrated that SPHINX31 induces cell cycle arrest and leukemic cell differentiation and prolongs survival of mice transplanted with MLL-rearranged AML through the modulation of the splicing of many genes with established roles in leukemogenesis such as MYB, BRD4, and MED24 (Tzelepis et al., 2018).